Somatostatin-14 vs Macimorelin
Head-to-head comparison of Somatostatin-14 (Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form)) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Somatostatin-14 | Macimorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form) | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 1637.9 Da | N/A |
| Half-Life | 1-3 minutes | about 4-6 hours |
| Amino Acids | 14 | N/A |
| Typical Dose | Research-only; microgram-scale bolus or infusion | 0.5 mg/kg single oral dose |
| Route | Intravenous/Subcutaneous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 120 |
| Research Status | Pre-clinical | Clinical |
Somatostatin-14 Benefits
- ✓GH suppression reference
- ✓somatostatin receptor mapping
- ✓GI hormone inhibition
- ✓endocrine research tool
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Somatostatin-14 Dosing
250 mcg IV bolus|250 mcg SC in short studies|continuous IV infusion in experimental settings
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Somatostatin-14 Side Effects
- ⚠bradycardia
- ⚠nausea
- ⚠glucose changes
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
Somatostatin-14
Somatostatin-14 established the core inhibitory biology of the GH axis and is widely used to study receptor subtype signaling. It remains a benchmark ligand for comparing synthetic analogs and endocrine pharmacology.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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