Larazotide vs P11-4
Head-to-head comparison of Larazotide (Larazotide acetate (AT-1001)) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Larazotide | P11-4 |
|---|---|---|
| Category | Gastrointestinal | Dental & Oral |
| Full Name | Larazotide acetate (AT-1001) | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | N/A | 1466 Da |
| Half-Life | short; designed for local gut action | local activity for hours; peptide degraded over time |
| Amino Acids | 8 | 11 |
| Typical Dose | 0.5-4 mg TID (clinical studies) | 0.5-5 mg per lesion |
| Route | Oral | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 40 |
| Research Status | Clinical | Clinical |
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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