P11-4 vs Secretin
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and Secretin (Human Secretin) — benefits, dosing, side effects, research data, and where to buy.
| Property | P11-4 | Secretin |
|---|---|---|
| Category | Dental & Oral | Gastrointestinal |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Human Secretin |
| Molecular Weight | 1466 Da | 3055.4 Da |
| Half-Life | local activity for hours; peptide degraded over time | 5-7 minutes |
| Amino Acids | 11 | 27 |
| Typical Dose | 0.5-5 mg per lesion | 0.2 mcg/kg IV |
| Route | Topical/Intraoral | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 800 |
| Research Status | Clinical | Clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
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