P11-4
Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)
11 Amino Acids · MW: 1466 Da
Amino Acids
11
Molecular Weight
1466 Da
Half-life
local activity for hours; peptide degraded over time
Research Score
5.0
Studies
40
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is P11-4?
A synthetic self-assembling peptide designed to form a scaffold in demineralized enamel and promote biomimetic remineralization. It is one of the best-known peptide approaches for early caries lesion repair.
Key Benefits & Mechanisms
enamel remineralization
early caries arrest
biomimetic scaffold formation
minimally invasive repair
Research Summary
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Related Peptides
Histatin-5
Human histatin 5
A salivary histidine-rich peptide with strong antifungal and antimicrobial properties in the oral cavity. It is widely studied for oral candidiasis and mucosal defense.
Dental & OralStatherin
Human statherin
A naturally occurring salivary phosphopeptide that binds hydroxyapatite and helps maintain calcium phosphate supersaturation in the mouth. It is important for enamel pellicle formation and inhibition of pathologic mineral deposition.
Dental & OralhBD-1
Human beta-defensin 1
A constitutively expressed epithelial antimicrobial peptide that contributes to innate oral defense. It is found in oral tissues and saliva and helps control bacterial and fungal colonization.
Dental & OralLRAP
Leucine-Rich Amelogenin Peptide (LRAP)
A naturally occurring amelogenin splice isoform associated with tooth development and mineralization signaling. It is studied for enamel and dentin regeneration, odontoblast differentiation, and restorative dental biomaterials.
Dental & Oral