P11-4 vs Histatin-5
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and Histatin-5 (Human histatin 5) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | P11-4 | Histatin-5 |
|---|---|---|
| Category | Dental & Oral | Dental & Oral |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Human histatin 5 |
| Molecular Weight | 1466 Da | 3035 Da |
| Half-Life | local activity for hours; peptide degraded over time | minutes in saliva |
| Amino Acids | 11 | 24 |
| Typical Dose | 0.5-5 mg per lesion | 1-100 µM in research formulations |
| Route | Topical/Intraoral | Topical/Oral rinse |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 120 |
| Research Status | Clinical | Pre-clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
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