P11-4 vs LRAP
Head-to-head comparison of P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) and LRAP (Leucine-Rich Amelogenin Peptide (LRAP)) — benefits, dosing, side effects, research data, and where to buy.
| Property | P11-4 | LRAP |
|---|---|---|
| Category | Dental & Oral | Dental & Oral |
| Full Name | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) | Leucine-Rich Amelogenin Peptide (LRAP) |
| Molecular Weight | 1466 Da | approx. 6.6 kDa |
| Half-Life | local activity for hours; peptide degraded over time | unknown |
| Amino Acids | 11 | 59 |
| Typical Dose | 0.5-5 mg per lesion | — |
| Route | Topical/Intraoral | local biomaterial |
| Purity | ≥98% | ≥98% |
| Studies Count | 40 | 85 |
| Research Status | Clinical | Pre-clinical |
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
LRAP Benefits
- ✓enamel/dentin regeneration
- ✓odontogenic signaling
- ✓mineralization support
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
LRAP Dosing
No dosing data available
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
LRAP Side Effects
- ⚠experimental only
- ⚠unknown immunogenicity
- ⚠biomaterial-dependent effects
Research Overview
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
LRAP
LRAP is one of the better-known amelogenin-derived peptides in regenerative dentistry because it can influence mineralization-related cell behavior. It remains a research peptide, but it is highly relevant to enamel repair and tooth-tissue engineering.
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