Histatin-5 vs Cholecystokinin-8
Head-to-head comparison of Histatin-5 (Human histatin 5) and Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | Cholecystokinin-8 |
|---|---|---|
| Category | Dental & Oral | Endocrine Peptides |
| Full Name | Human histatin 5 | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) |
| Molecular Weight | 3035 Da | 1143.2 Da |
| Half-Life | minutes in saliva | 1-2 min |
| Amino Acids | 24 | DY(SO3H)MGWMDF-NH2 |
| Typical Dose | 1-100 µM in research formulations | physiologic low-picomolar-nanomolar range|research-dependent |
| Route | Topical/Oral rinse | endogenous secretion|research IV/SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 97 |
| Research Status | Pre-clinical | Endogenous |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
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