Histatin-5 vs P11-4
Head-to-head comparison of Histatin-5 (Human histatin 5) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Histatin-5 | P11-4 |
|---|---|---|
| Category | Dental & Oral | Dental & Oral |
| Full Name | Human histatin 5 | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 3035 Da | 1466 Da |
| Half-Life | minutes in saliva | local activity for hours; peptide degraded over time |
| Amino Acids | 24 | 11 |
| Typical Dose | 1-100 µM in research formulations | 0.5-5 mg per lesion |
| Route | Topical/Oral rinse | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 40 |
| Research Status | Pre-clinical | Clinical |
Histatin-5 Benefits
- ✓anti-Candida activity
- ✓biofilm suppression
- ✓mucosal wound support
- ✓oral innate immunity
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
Histatin-5 Dosing
topical rinse or gel|short contact exposure|repeat applications in research protocols
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
Histatin-5 Side Effects
- ⚠local irritation
- ⚠proteolytic instability
- ⚠dose-dependent cytotoxicity in vitro
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
Histatin-5
Histatin-5 is a major salivary defense peptide that can kill Candida species and influence oral microbial communities. It is also investigated for wound-healing and xerostomia-associated oral infection models.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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