GLP-1(7-36) amide vs hGHRH(1-44)

Head-to-head comparison of GLP-1(7-36) amide (Glucagon-like peptide-1 (7-36) amide) and hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) — benefits, dosing, side effects, research data, and where to buy.

PropertyGLP-1(7-36) amidehGHRH(1-44)
CategoryEndocrine PeptidesGrowth Hormone
Full NameGlucagon-like peptide-1 (7-36) amideHuman growth hormone-releasing hormone (1-44) amide
Molecular Weight3297.7 DaN/A
Half-Life1-2 min5-15 minutes
Amino AcidsHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH244
Typical DosepM-nM physiologic range|research-dependent0.1-1 mcg/kg
Routeendogenous secretion|SC/IV in research/clinical analog studiesSubcutaneous/IV
Purity≥98%≥98%
Studies Count99120
Research StatusEndogenousClinical Research

GLP-1(7-36) amide Benefits

  • glucose-dependent insulin secretion
  • gastric emptying delay
  • satiety signaling

hGHRH(1-44) Benefits

  • physiologic GH pulse support
  • IGF-1 pathway stimulation
  • pituitary receptor mapping
  • endocrine research tool

GLP-1(7-36) amide Dosing

physiologic secretion|research-dependent

hGHRH(1-44) Dosing

0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments

GLP-1(7-36) amide Side Effects

  • nausea
  • fullness
  • reduced appetite

hGHRH(1-44) Side Effects

  • flushing
  • headache
  • transient nausea

Research Overview

GLP-1(7-36) amide

One of the best-studied gut hormones, with strong evidence for incretin biology and appetite regulation. Native GLP-1 is rapidly degraded by DPP-4, which is why its biology is central to endocrine and metabolic pharmacology.

hGHRH(1-44)

Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.

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Common Stacking Partners

GLP-1(7-36) amide stacks with:

L-cellsinsulinsatiety

hGHRH(1-44) stacks with:

L-arginineL-lysineglycine
gut-hormoneincretinendocrine-peptideghrhendogenous-peptidepituitarysomatotropic-axis