Ghrelin vs Somatostatin-14
Head-to-head comparison of Ghrelin (Ghrelin (acylated human ghrelin; endogenous growth hormone secretagogue)) and Somatostatin-14 (Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Ghrelin | Somatostatin-14 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ghrelin (acylated human ghrelin; endogenous growth hormone secretagogue) | Somatostatin (somatotropin release-inhibiting factor, 14-amino-acid form) |
| Molecular Weight | 3367 Da | 1637.9 Da |
| Half-Life | 20-30 minutes | 1-3 minutes |
| Amino Acids | 28 | 14 |
| Typical Dose | 1-3 mcg/kg | Research-only; microgram-scale bolus or infusion |
| Route | Subcutaneous/Intravenous | Intravenous/Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 2000 |
| Research Status | Clinical research | Pre-clinical |
Ghrelin Benefits
- ✓increases GH pulses
- ✓supports appetite and energy intake
- ✓may support lean mass preservation
- ✓promotes recovery signaling
Somatostatin-14 Benefits
- ✓GH suppression reference
- ✓somatostatin receptor mapping
- ✓GI hormone inhibition
- ✓endocrine research tool
Ghrelin Dosing
1-3 mcg/kg SC or IV|repeat dosing in short research windows|titrate to GH response in monitored studies
Somatostatin-14 Dosing
250 mcg IV bolus|250 mcg SC in short studies|continuous IV infusion in experimental settings
Ghrelin Side Effects
- ⚠hunger/nausea
- ⚠transient flushing
- ⚠changes in glucose/insulin
Somatostatin-14 Side Effects
- ⚠bradycardia
- ⚠nausea
- ⚠glucose changes
Research Overview
Ghrelin
Ghrelin is the canonical ligand for the growth hormone secretagogue receptor and is used extensively as a reference compound in GH-axis research. Human and animal studies consistently show rapid, dose-dependent GH release after acyl-ghrelin administration.
Somatostatin-14
Somatostatin-14 established the core inhibitory biology of the GH axis and is widely used to study receptor subtype signaling. It remains a benchmark ligand for comparing synthetic analogs and endocrine pharmacology.
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