Ghrelin vs Anamorelin
Head-to-head comparison of Ghrelin (Ghrelin (acylated human ghrelin; endogenous growth hormone secretagogue)) and Anamorelin (Anamorelin hydrochloride (ONO-7643)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Ghrelin | Anamorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ghrelin (acylated human ghrelin; endogenous growth hormone secretagogue) | Anamorelin hydrochloride (ONO-7643) |
| Molecular Weight | 3367 Da | N/A |
| Half-Life | 20-30 minutes | about 9 hours |
| Amino Acids | 28 | N/A |
| Typical Dose | 1-3 mcg/kg | 50 mg/day |
| Route | Subcutaneous/Intravenous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 95 |
| Research Status | Clinical research | Clinical |
Ghrelin Benefits
- ✓increases GH pulses
- ✓supports appetite and energy intake
- ✓may support lean mass preservation
- ✓promotes recovery signaling
Anamorelin Benefits
- ✓stimulates appetite
- ✓raises IGF-1
- ✓may support weight gain
- ✓oral dosing
Ghrelin Dosing
1-3 mcg/kg SC or IV|repeat dosing in short research windows|titrate to GH response in monitored studies
Anamorelin Dosing
50 mg orally once daily|often studied with food or per protocol|track weight, appetite, and glucose markers
Ghrelin Side Effects
- ⚠hunger/nausea
- ⚠transient flushing
- ⚠changes in glucose/insulin
Anamorelin Side Effects
- ⚠hyperglycemia
- ⚠peripheral edema
- ⚠constipation or nausea
Research Overview
Ghrelin
Ghrelin is the canonical ligand for the growth hormone secretagogue receptor and is used extensively as a reference compound in GH-axis research. Human and animal studies consistently show rapid, dose-dependent GH release after acyl-ghrelin administration.
Anamorelin
Trials in cachexia populations showed increased appetite and modest gains in body weight and IGF-1. Regulatory progress has varied by region, but it remains a well-studied ghrelin agonist in the GH space.
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