Ghrelin
Ghrelin (acylated human ghrelin; endogenous growth hormone secretagogue)
28 Amino Acids · MW: 3367 Da
Amino Acids
28
Molecular Weight
3367 Da
Half-life
20-30 minutes
Research Score
4.9
Studies
2000
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Ghrelin?
Ghrelin is the endogenous 28-amino-acid peptide hormone best known for activating GHSR1a and triggering growth hormone release. Its Ser3 octanoylation is required for strong receptor activity and is the key modification that makes it a potent secretagogue.
Key Benefits & Mechanisms
increases GH pulses
supports appetite and energy intake
may support lean mass preservation
promotes recovery signaling
Research Summary
Ghrelin is the canonical ligand for the growth hormone secretagogue receptor and is used extensively as a reference compound in GH-axis research. Human and animal studies consistently show rapid, dose-dependent GH release after acyl-ghrelin administration.
Related Peptides
Ibutamoren
Ibutamoren mesylate (MK-677)
Ibutamoren is an orally active ghrelin receptor agonist that increases pulsatile growth hormone and IGF-1 secretion. It has been studied for effects on lean mass, recovery, and age-related anabolic support.
Growth HormoneAnamorelin
Anamorelin hydrochloride (ONO-7643)
Anamorelin is a selective ghrelin receptor agonist developed to stimulate appetite and growth hormone signaling. It has been investigated primarily in cancer cachexia and other wasting states.
Growth HormoneMacimorelin
Macimorelin acetate (AEZS-130)
Macimorelin is an orally active ghrelin mimetic used as a growth hormone stimulation agent. It produces a rapid GH rise after a single dose and is used clinically to help diagnose adult GH deficiency.
Growth HormoneCapromorelin
Capromorelin hydrochloride
Capromorelin is a ghrelin receptor agonist that stimulates growth hormone release and increases appetite. It is best known in veterinary medicine, but it has also been explored in human research settings.
Growth Hormone