DPDPE vs Larazotide
Head-to-head comparison of DPDPE ([D-Pen2, D-Pen5]-enkephalin) and Larazotide (Larazotide acetate (AT-1001)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | DPDPE | Larazotide |
|---|---|---|
| Category | Pain Management | Gastrointestinal |
| Full Name | [D-Pen2, D-Pen5]-enkephalin | Larazotide acetate (AT-1001) |
| Molecular Weight | 645.79 Da | N/A |
| Half-Life | 15-60 minutes in plasma | short; designed for local gut action |
| Amino Acids | 5 | 8 |
| Typical Dose | 0.01-1 ug per animal | 0.5-4 mg TID (clinical studies) |
| Route | Intrathecal / intracerebroventricular | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 40 |
| Research Status | Pre-clinical | Clinical |
DPDPE Benefits
- ✓delta-opioid selectivity
- ✓improved conformational stability
- ✓analgesic receptor mapping
- ✓useful in chronic pain models
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
DPDPE Dosing
Intrathecal 0.01-1 ug per animal|Intracerebroventricular 0.01-0.5 ug per animal|In vitro 0.1-20 nM
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
DPDPE Side Effects
- ⚠sedation
- ⚠nausea-like opioid effects
- ⚠tolerance with repeated dosing
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Research Overview
DPDPE
DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
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