DPDPE vs Endomorphin-1
Head-to-head comparison of DPDPE ([D-Pen2, D-Pen5]-enkephalin) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | DPDPE | Endomorphin-1 |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | [D-Pen2, D-Pen5]-enkephalin | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 645.79 Da | 610.71 Da |
| Half-Life | 15-60 minutes in plasma | Minutes in plasma |
| Amino Acids | 5 | 4 |
| Typical Dose | 0.01-1 ug per animal | 0.1-10 ug per animal |
| Route | Intrathecal / intracerebroventricular | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 600 |
| Research Status | Pre-clinical | Pre-clinical |
DPDPE Benefits
- ✓delta-opioid selectivity
- ✓improved conformational stability
- ✓analgesic receptor mapping
- ✓useful in chronic pain models
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
DPDPE Dosing
Intrathecal 0.01-1 ug per animal|Intracerebroventricular 0.01-0.5 ug per animal|In vitro 0.1-20 nM
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
DPDPE Side Effects
- ⚠sedation
- ⚠nausea-like opioid effects
- ⚠tolerance with repeated dosing
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
DPDPE
DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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