DPDPE vs DADLE
Head-to-head comparison of DPDPE ([D-Pen2, D-Pen5]-enkephalin) and DADLE ([D-Ala2, D-Leu5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
| Property | DPDPE | DADLE |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | [D-Pen2, D-Pen5]-enkephalin | [D-Ala2, D-Leu5]-enkephalin |
| Molecular Weight | 645.79 Da | 569.67 Da |
| Half-Life | 15-60 minutes in plasma | 5-20 minutes in plasma |
| Amino Acids | 5 | 5 |
| Typical Dose | 0.01-1 ug per animal | 0.01-2 ug per animal |
| Route | Intrathecal / intracerebroventricular | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 450 |
| Research Status | Pre-clinical | Pre-clinical |
DPDPE Benefits
- ✓delta-opioid selectivity
- ✓improved conformational stability
- ✓analgesic receptor mapping
- ✓useful in chronic pain models
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
DPDPE Dosing
Intrathecal 0.01-1 ug per animal|Intracerebroventricular 0.01-0.5 ug per animal|In vitro 0.1-20 nM
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
DPDPE Side Effects
- ⚠sedation
- ⚠nausea-like opioid effects
- ⚠tolerance with repeated dosing
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Research Overview
DPDPE
DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
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