DADLE vs P11-4
Head-to-head comparison of DADLE ([D-Ala2, D-Leu5]-enkephalin) and P11-4 (Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2)) — benefits, dosing, side effects, research data, and where to buy.
| Property | DADLE | P11-4 |
|---|---|---|
| Category | Pain Management | Dental & Oral |
| Full Name | [D-Ala2, D-Leu5]-enkephalin | Self-assembling peptide P11-4 (Ac-QQRFEWEFEQQ-NH2) |
| Molecular Weight | 569.67 Da | 1466 Da |
| Half-Life | 5-20 minutes in plasma | local activity for hours; peptide degraded over time |
| Amino Acids | 5 | 11 |
| Typical Dose | 0.01-2 ug per animal | 0.5-5 mg per lesion |
| Route | Intrathecal / intracerebroventricular | Topical/Intraoral |
| Purity | ≥98% | ≥98% |
| Studies Count | 450 | 40 |
| Research Status | Pre-clinical | Clinical |
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
P11-4 Benefits
- ✓enamel remineralization
- ✓early caries arrest
- ✓biomimetic scaffold formation
- ✓minimally invasive repair
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
P11-4 Dosing
topical application to cleaned lesion|single-visit in-office application|repeat at follow-up if indicated
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
P11-4 Side Effects
- ⚠transient tooth sensitivity
- ⚠local irritation
- ⚠taste disturbance
Research Overview
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
P11-4
P11-4 has been studied for its ability to penetrate initial carious lesions and self-assemble into a fibrillar matrix that nucleates hydroxyapatite. Human and preclinical studies support its role in non-invasive enamel repair.
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