Cholecystokinin-8 vs Trefoil factor 2
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Trefoil factor 2 (Trefoil factor 2 (Spasmolytic Polypeptide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Trefoil factor 2 |
|---|---|---|
| Category | Endocrine Peptides | Gastrointestinal |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Trefoil factor 2 (Spasmolytic Polypeptide) |
| Molecular Weight | 1143.2 Da | ≈11–12 kDa |
| Half-Life | 1-2 min | Unknown |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 106 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | none established |
| Route | endogenous secretion|research IV/SC | oral/enteral|research-only |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 80 |
| Research Status | Endogenous | Pre-clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Trefoil factor 2 Benefits
- ✓epithelial restitution
- ✓barrier protection
- ✓ulcer healing
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Trefoil factor 2 Dosing
No established clinical dose|preclinical only
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Trefoil factor 2 Side Effects
- ⚠limited human data
- ⚠theoretical growth-factor concerns
- ⚠GI discomfort
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Trefoil factor 2
TFF2 strengthens mucus-barrier repair and epithelial restitution after gastric injury in experimental systems, making it a well-known gastric-protective peptide.
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