Cholecystokinin-8 vs Motilin
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Motilin (Motilin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Motilin |
|---|---|---|
| Category | Endocrine Peptides | Gastrointestinal |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Motilin |
| Molecular Weight | 1143.2 Da | ~2.7 kDa |
| Half-Life | 1-2 min | ~20 min |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 22 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | No standard approved dose; experimental use only |
| Route | endogenous secretion|research IV/SC | IV|SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 81 |
| Research Status | Endogenous | Endogenous |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Motilin Benefits
- ✓migrating motor complex support
- ✓gastric emptying
- ✓small-bowel clearance
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Motilin Dosing
0.1–1 mg (experimental)|IV/SC
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Motilin Side Effects
- ⚠cramping
- ⚠nausea
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Motilin
Motilin is a 22-amino-acid peptide released from the upper small intestine and is one of the classic physiologic prokinetic signals. It is a real peptide target for GI motility research, though not commonly used as a standard drug.
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