Cholecystokinin-8 vs hCG
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and hCG (Human Chorionic Gonadotropin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | hCG |
|---|---|---|
| Category | Endocrine Peptides | Sexual Health |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Human Chorionic Gonadotropin |
| Molecular Weight | 1143.2 Da | 36,700 Da |
| Half-Life | 1-2 min | ~24-36 hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | N/A |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 500-2,000 IU per dose |
| Route | endogenous secretion|research IV/SC | Subcutaneous/Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 2000 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
hCG Benefits
- ✓stimulates endogenous testosterone
- ✓supports spermatogenesis
- ✓preserves testicular volume
- ✓may improve fertility markers
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
hCG Dosing
500-2,000 IU SC/IM 2-3x weekly|1,500-3,000 IU weekly in fertility protocols|titrate to testosterone, estradiol, and semen parameters
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
hCG Side Effects
- ⚠acne
- ⚠gynecomastia
- ⚠water retention
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
hCG
Human studies show hCG can raise intratesticular and serum testosterone by mimicking luteinizing hormone at the testis. It is commonly studied in male hypogonadism and fertility-preservation settings.
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