Cholecystokinin-8 vs Bremelanotide
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Bremelanotide (Bremelanotide (PT-141), cyclic melanocortin receptor agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Bremelanotide |
|---|---|---|
| Category | Endocrine Peptides | Sexual Health |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Bremelanotide (PT-141), cyclic melanocortin receptor agonist |
| Molecular Weight | 1143.2 Da | 1025.2 Da |
| Half-Life | 1-2 min | about 2.7 h |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 7 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 1.75 mg |
| Route | endogenous secretion|research IV/SC | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 200 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Bremelanotide Benefits
- ✓increases sexual desire
- ✓supports arousal
- ✓may improve erectile response
- ✓on-demand use
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Bremelanotide Dosing
1.75 mg subcutaneous PRN|administer about 45 minutes before activity|max 1 dose per 24 hours
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Bremelanotide Side Effects
- ⚠nausea
- ⚠flushing
- ⚠headache
- ⚠transient blood pressure increase
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Bremelanotide
Human studies and approval data support meaningful effects on sexual desire in women, with a central mechanism involving melanocortin signaling. It is one of the most clinically relevant peptides in this category and is commonly used as the reference compound for PT-141-type research.
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