Cholecystokinin-8 vs Kisspeptin-52
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Kisspeptin-52 (Kisspeptin-52 (KISS1-derived peptide fragment)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Kisspeptin-52 |
|---|---|---|
| Category | Endocrine Peptides | Sexual Health |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Kisspeptin-52 (KISS1-derived peptide fragment) |
| Molecular Weight | 1143.2 Da | ≈5,800 Da |
| Half-Life | 1-2 min | Minutes to ~1 hour |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 52 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.1-3.0 nmol/kg |
| Route | endogenous secretion|research IV/SC | Intravenous/Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 120 |
| Research Status | Endogenous | Clinical research |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Kisspeptin-52 Benefits
- ✓stimulates GnRH signaling
- ✓supports LH/FSH release
- ✓aids ovulation research
- ✓maps reproductive-axis function
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Kisspeptin-52 Dosing
0.1-3.0 nmol/kg IV bolus|0.1-1.0 nmol/kg SC|protocol-dependent infusion
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Kisspeptin-52 Side Effects
- ⚠flushing
- ⚠nausea
- ⚠headache
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Kisspeptin-52
Human and animal studies show kisspeptin-52 can acutely increase gonadotropin secretion and activate the hypothalamic-pituitary-gonadal axis. It has been explored in fertility research and assisted-reproduction settings as a way to trigger endogenous reproductive hormone release.
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