Cholecystokinin-8 vs Kisspeptin-54
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Kisspeptin-54 (Kisspeptin-54 (metastin), 54-amino-acid KISS1 peptide fragment) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Kisspeptin-54 |
|---|---|---|
| Category | Endocrine Peptides | Sexual Health |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Kisspeptin-54 (metastin), 54-amino-acid KISS1 peptide fragment |
| Molecular Weight | 1143.2 Da | 5.9 kDa |
| Half-Life | 1-2 min | about 20-30 min |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 54 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.3-1.0 nmol/kg |
| Route | endogenous secretion|research IV/SC | Intravenous |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 110 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Kisspeptin-54 Benefits
- ✓GnRH/LH stimulation
- ✓supports sex hormone signaling
- ✓may enhance sexual motivation
- ✓fertility-axis modulation
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Kisspeptin-54 Dosing
0.3-1.0 nmol/kg IV bolus|single-dose experimental protocols|research-only endocrine monitoring
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Kisspeptin-54 Side Effects
- ⚠flushing
- ⚠nausea
- ⚠headache
- ⚠hormonal shifts
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Kisspeptin-54
Human studies show that kisspeptin-54 can acutely modulate reproductive neuroendocrine signaling, which makes it relevant to libido and sexual motivation research. Its effects are indirect compared with PT-141, but it is a well-established peptide in the scientific literature.
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