hCG vs Follitropin alfa
Head-to-head comparison of hCG (Human Chorionic Gonadotropin) and Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | hCG | Follitropin alfa |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Human Chorionic Gonadotropin | Recombinant Human Follicle-Stimulating Hormone Alfa |
| Molecular Weight | 36,700 Da | 30,000 Da |
| Half-Life | ~24-36 hours | ~24 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 500-2,000 IU per dose | 75-150 IU per dose |
| Route | Subcutaneous/Intramuscular | Subcutaneous/Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 2000 | 850 |
| Research Status | Clinical | Clinical |
hCG Benefits
- ✓stimulates endogenous testosterone
- ✓supports spermatogenesis
- ✓preserves testicular volume
- ✓may improve fertility markers
Follitropin alfa Benefits
- ✓supports spermatogenesis
- ✓improves Sertoli cell signaling
- ✓may enhance sperm parameters
- ✓complements LH-driven testosterone support
hCG Dosing
500-2,000 IU SC/IM 2-3x weekly|1,500-3,000 IU weekly in fertility protocols|titrate to testosterone, estradiol, and semen parameters
Follitropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men
hCG Side Effects
- ⚠acne
- ⚠gynecomastia
- ⚠water retention
Follitropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠bloating
Research Overview
hCG
Human studies show hCG can raise intratesticular and serum testosterone by mimicking luteinizing hormone at the testis. It is commonly studied in male hypogonadism and fertility-preservation settings.
Follitropin alfa
Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.
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