Follitropin alfa vs Nafarelin
Head-to-head comparison of Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) and Nafarelin (Nafarelin acetate) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Follitropin alfa | Nafarelin |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Recombinant Human Follicle-Stimulating Hormone Alfa | Nafarelin acetate |
| Molecular Weight | 30,000 Da | 1321.47 Da |
| Half-Life | ~24 hours | ~2-4 hours |
| Amino Acids | N/A | 10 |
| Typical Dose | 75-150 IU per dose | 200 mcg intranasal twice daily |
| Route | Subcutaneous/Intramuscular | Intranasal |
| Purity | ≥98% | ≥98% |
| Studies Count | 850 | 220 |
| Research Status | Clinical | Clinical |
Follitropin alfa Benefits
- ✓supports spermatogenesis
- ✓improves Sertoli cell signaling
- ✓may enhance sperm parameters
- ✓complements LH-driven testosterone support
Nafarelin Benefits
- ✓pituitary suppression
- ✓cycle scheduling
- ✓endometriosis-related reproductive care
- ✓controlled hormone modulation
Follitropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men
Nafarelin Dosing
200 mcg intranasal twice daily|0.4 mg/day intranasal|protocol-based suppression cycles
Follitropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠bloating
Nafarelin Side Effects
- ⚠nasal irritation
- ⚠hot flashes
- ⚠headache
Research Overview
Follitropin alfa
Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.
Nafarelin
Nafarelin has a long history in reproductive medicine, especially for endometriosis and cycle suppression. Studies show it down-regulates the HPG axis after an initial stimulatory flare.
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