Nafarelin vs Cetrorelix
Head-to-head comparison of Nafarelin (Nafarelin acetate) and Cetrorelix (Cetrorelix acetate) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Nafarelin | Cetrorelix |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Nafarelin acetate | Cetrorelix acetate |
| Molecular Weight | 1321.47 Da | 1431.06 Da |
| Half-Life | ~2-4 hours | ~30 hours |
| Amino Acids | 10 | 10 |
| Typical Dose | 200 mcg intranasal twice daily | 0.25 mg SC daily |
| Route | Intranasal | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 220 | 300 |
| Research Status | Clinical | Clinical |
Nafarelin Benefits
- ✓pituitary suppression
- ✓cycle scheduling
- ✓endometriosis-related reproductive care
- ✓controlled hormone modulation
Cetrorelix Benefits
- ✓prevents premature ovulation
- ✓supports IVF cycle control
- ✓blocks LH surge
- ✓short-acting pituitary suppression
Nafarelin Dosing
200 mcg intranasal twice daily|0.4 mg/day intranasal|protocol-based suppression cycles
Cetrorelix Dosing
0.25 mg SC daily|start on stimulation day 5-6|protocol-dependent antagonist cycle
Nafarelin Side Effects
- ⚠nasal irritation
- ⚠hot flashes
- ⚠headache
Cetrorelix Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠nausea
Research Overview
Nafarelin
Nafarelin has a long history in reproductive medicine, especially for endometriosis and cycle suppression. Studies show it down-regulates the HPG axis after an initial stimulatory flare.
Cetrorelix
Cetrorelix is a cornerstone GnRH antagonist in assisted reproduction, with a fast onset and reversible suppression of LH. Trials show it improves cycle management by reducing premature ovulation during stimulation.
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