Cetrorelix vs Leuprolide
Head-to-head comparison of Cetrorelix (Cetrorelix acetate) and Leuprolide (Leuprolide acetate) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cetrorelix | Leuprolide |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Cetrorelix acetate | Leuprolide acetate |
| Molecular Weight | 1431.06 Da | 1209.39 Da |
| Half-Life | ~30 hours | ~3 hours; depot lasts weeks |
| Amino Acids | 10 | 9 |
| Typical Dose | 0.25 mg SC daily | 0.1 mg SC daily|3.75 mg IM monthly|11.25 mg depot per protocol |
| Route | Subcutaneous | Subcutaneous/Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 300 | 1200 |
| Research Status | Clinical | Clinical |
Cetrorelix Benefits
- ✓prevents premature ovulation
- ✓supports IVF cycle control
- ✓blocks LH surge
- ✓short-acting pituitary suppression
Leuprolide Benefits
- ✓pituitary suppression
- ✓cycle synchronization
- ✓ovarian stimulation timing
- ✓endometriosis-related reproductive care
Cetrorelix Dosing
0.25 mg SC daily|start on stimulation day 5-6|protocol-dependent antagonist cycle
Leuprolide Dosing
0.1 mg SC daily|3.75 mg IM monthly depot|11.25 mg 3-month depot
Cetrorelix Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠nausea
Leuprolide Side Effects
- ⚠hot flashes
- ⚠decreased libido
- ⚠injection-site reactions
Research Overview
Cetrorelix
Cetrorelix is a cornerstone GnRH antagonist in assisted reproduction, with a fast onset and reversible suppression of LH. Trials show it improves cycle management by reducing premature ovulation during stimulation.
Leuprolide
Leuprolide is one of the best-studied GnRH analogs in reproductive medicine and assisted reproduction. It produces an initial flare followed by receptor desensitization and reduced LH/FSH output.
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