Follitropin alfa vs Bremelanotide
Head-to-head comparison of Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) and Bremelanotide (Bremelanotide (PT-141), cyclic melanocortin receptor agonist) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Follitropin alfa | Bremelanotide |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Recombinant Human Follicle-Stimulating Hormone Alfa | Bremelanotide (PT-141), cyclic melanocortin receptor agonist |
| Molecular Weight | 30,000 Da | 1025.2 Da |
| Half-Life | ~24 hours | about 2.7 h |
| Amino Acids | N/A | 7 |
| Typical Dose | 75-150 IU per dose | 1.75 mg |
| Route | Subcutaneous/Intramuscular | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 850 | 200 |
| Research Status | Clinical | Clinical |
Follitropin alfa Benefits
- ✓supports spermatogenesis
- ✓improves Sertoli cell signaling
- ✓may enhance sperm parameters
- ✓complements LH-driven testosterone support
Bremelanotide Benefits
- ✓increases sexual desire
- ✓supports arousal
- ✓may improve erectile response
- ✓on-demand use
Follitropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men
Bremelanotide Dosing
1.75 mg subcutaneous PRN|administer about 45 minutes before activity|max 1 dose per 24 hours
Follitropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠bloating
Bremelanotide Side Effects
- ⚠nausea
- ⚠flushing
- ⚠headache
- ⚠transient blood pressure increase
Research Overview
Follitropin alfa
Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.
Bremelanotide
Human studies and approval data support meaningful effects on sexual desire in women, with a central mechanism involving melanocortin signaling. It is one of the most clinically relevant peptides in this category and is commonly used as the reference compound for PT-141-type research.
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