Follitropin alfa vs Lutropin alfa
Head-to-head comparison of Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) and Lutropin alfa (Recombinant Human Luteinizing Hormone Alfa) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Follitropin alfa | Lutropin alfa |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Recombinant Human Follicle-Stimulating Hormone Alfa | Recombinant Human Luteinizing Hormone Alfa |
| Molecular Weight | 30,000 Da | 30,000 Da |
| Half-Life | ~24 hours | ~10-12 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 75-150 IU per dose | 75-150 IU per dose |
| Route | Subcutaneous/Intramuscular | Subcutaneous/Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 850 | 420 |
| Research Status | Clinical | Clinical |
Follitropin alfa Benefits
- ✓supports spermatogenesis
- ✓improves Sertoli cell signaling
- ✓may enhance sperm parameters
- ✓complements LH-driven testosterone support
Lutropin alfa Benefits
- ✓stimulates Leydig cells
- ✓raises endogenous testosterone
- ✓supports testicular steroidogenesis
- ✓pairs with FSH for fertility
Follitropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men
Lutropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust to testosterone response|combine with FSH when spermatogenesis support is needed
Follitropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠bloating
Lutropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠hormonal swings
Research Overview
Follitropin alfa
Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.
Lutropin alfa
Lutropin alfa has been evaluated in fertility protocols to restore LH signaling and endogenous testosterone production. It is a direct research/clinical analogue for men with low gonadotropin drive.
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