Follitropin alfa vs Cetrorelix
Head-to-head comparison of Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) and Cetrorelix (Cetrorelix acetate) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Follitropin alfa | Cetrorelix |
|---|---|---|
| Category | Sexual Health | Sexual Health |
| Full Name | Recombinant Human Follicle-Stimulating Hormone Alfa | Cetrorelix acetate |
| Molecular Weight | 30,000 Da | 1431.06 Da |
| Half-Life | ~24 hours | ~30 hours |
| Amino Acids | N/A | 10 |
| Typical Dose | 75-150 IU per dose | 0.25 mg SC daily |
| Route | Subcutaneous/Intramuscular | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 850 | 300 |
| Research Status | Clinical | Clinical |
Follitropin alfa Benefits
- ✓supports spermatogenesis
- ✓improves Sertoli cell signaling
- ✓may enhance sperm parameters
- ✓complements LH-driven testosterone support
Cetrorelix Benefits
- ✓prevents premature ovulation
- ✓supports IVF cycle control
- ✓blocks LH surge
- ✓short-acting pituitary suppression
Follitropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men
Cetrorelix Dosing
0.25 mg SC daily|start on stimulation day 5-6|protocol-dependent antagonist cycle
Follitropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠bloating
Cetrorelix Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠nausea
Research Overview
Follitropin alfa
Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.
Cetrorelix
Cetrorelix is a cornerstone GnRH antagonist in assisted reproduction, with a fast onset and reversible suppression of LH. Trials show it improves cycle management by reducing premature ovulation during stimulation.
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