Cholecystokinin-8 vs Follitropin alfa
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Follitropin alfa (Recombinant Human Follicle-Stimulating Hormone Alfa) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Follitropin alfa |
|---|---|---|
| Category | Endocrine Peptides | Sexual Health |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | Recombinant Human Follicle-Stimulating Hormone Alfa |
| Molecular Weight | 1143.2 Da | 30,000 Da |
| Half-Life | 1-2 min | ~24 hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | N/A |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 75-150 IU per dose |
| Route | endogenous secretion|research IV/SC | Subcutaneous/Intramuscular |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 850 |
| Research Status | Endogenous | Clinical |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Follitropin alfa Benefits
- ✓supports spermatogenesis
- ✓improves Sertoli cell signaling
- ✓may enhance sperm parameters
- ✓complements LH-driven testosterone support
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Follitropin alfa Dosing
75-150 IU SC/IM 2-3x weekly|adjust based on FSH and semen analysis|often combined with hCG in men
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Follitropin alfa Side Effects
- ⚠injection-site reactions
- ⚠headache
- ⚠bloating
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Follitropin alfa
Clinical literature supports follitropin alfa for male infertility, especially when combined with LH activity to optimize testicular output. Its role is strongest in hypogonadotropic hypogonadism and assisted reproduction protocols.
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