C-peptide vs Met-enkephalin
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | Met-enkephalin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Connecting peptide (C-peptide) | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 3020.3 Da | 573.67 Da |
| Half-Life | ~20-30 min | 1-5 minutes in plasma |
| Amino Acids | 31 | 5 |
| Typical Dose | no approved analgesic dose|research-only | 0.1-5 ug per animal |
| Route | IV|subQ | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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