C-peptide vs Cholecystokinin-8
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | Cholecystokinin-8 |
|---|---|---|
| Category | Pain Management | Endocrine Peptides |
| Full Name | Connecting peptide (C-peptide) | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) |
| Molecular Weight | 3020.3 Da | 1143.2 Da |
| Half-Life | ~20-30 min | 1-2 min |
| Amino Acids | 31 | DY(SO3H)MGWMDF-NH2 |
| Typical Dose | no approved analgesic dose|research-only | physiologic low-picomolar-nanomolar range|research-dependent |
| Route | IV|subQ | endogenous secretion|research IV/SC |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 97 |
| Research Status | Pre-clinical | Endogenous |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
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