Cholecystokinin-8 vs Ziconotide
Head-to-head comparison of Cholecystokinin-8 (Cholecystokinin (sulfated C-terminal octapeptide, CCK-8)) and Ziconotide (ω-Conotoxin MVIIA (ziconotide)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Cholecystokinin-8 | Ziconotide |
|---|---|---|
| Category | Endocrine Peptides | Pain Management |
| Full Name | Cholecystokinin (sulfated C-terminal octapeptide, CCK-8) | ω-Conotoxin MVIIA (ziconotide) |
| Molecular Weight | 1143.2 Da | 2639.1 Da |
| Half-Life | 1-2 min | approximately 4.5 hours |
| Amino Acids | DY(SO3H)MGWMDF-NH2 | 25 |
| Typical Dose | physiologic low-picomolar-nanomolar range|research-dependent | 0.5-19.2 mcg/day |
| Route | endogenous secretion|research IV/SC | Intrathecal |
| Purity | ≥98% | ≥98% |
| Studies Count | 97 | 500 |
| Research Status | Endogenous | Approved |
Cholecystokinin-8 Benefits
- ✓gallbladder contraction
- ✓pancreatic enzyme release
- ✓satiety signaling
Ziconotide Benefits
- ✓strong non-opioid analgesia
- ✓effective for refractory neuropathic pain
- ✓opioid-sparing option
- ✓intrathecal delivery allows targeted action
Cholecystokinin-8 Dosing
physiologic secretion|research-dependent
Ziconotide Dosing
start 0.5 mcg/day intrathecal|titrate by 0.5 mcg/day no more than 2 times weekly|max 19.2 mcg/day in labeling
Cholecystokinin-8 Side Effects
- ⚠abdominal cramping
- ⚠nausea
- ⚠biliary contraction
Ziconotide Side Effects
- ⚠dizziness
- ⚠confusion
- ⚠ataxia
Research Overview
Cholecystokinin-8
CCK-8 is a canonical gut hormone fragment with extensive documentation in digestive physiology and appetite control. Sulfation of the tyrosine residue is important for high-affinity receptor activity.
Ziconotide
Clinical studies and post-marketing data support ziconotide as an analgesic for severe chronic pain that does not respond to conventional therapy. Research focuses on balancing analgesic efficacy with neuropsychiatric tolerability and careful dose titration.
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