Ziconotide

ω-Conotoxin MVIIA (ziconotide)

25 Amino Acids · MW: 2639.1 Da

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Amino Acids

Molecular Weight

2639.1 Da

Half-life

approximately 4.5 hours

Research Score

4.9

Studies

500

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Ziconotide?

A synthetic 25-amino-acid peptide derived from cone snail venom that blocks N-type voltage-gated calcium channels. It is one of the few non-opioid peptides approved for severe chronic pain, especially when delivered intrathecally.

Key Benefits & Mechanisms

strong non-opioid analgesia

effective for refractory neuropathic pain

opioid-sparing option

intrathecal delivery allows targeted action

Research Summary

Clinical studies and post-marketing data support ziconotide as an analgesic for severe chronic pain that does not respond to conventional therapy. Research focuses on balancing analgesic efficacy with neuropsychiatric tolerability and careful dose titration.

Related Peptides

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Tyr-Gly-Gly-Phe-Met

Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.

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Leu-enkephalin

Tyr-Gly-Gly-Phe-Leu

Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.

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DADLE

[D-Ala2, D-Leu5]-enkephalin

DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.

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DPDPE

[D-Pen2, D-Pen5]-enkephalin

DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.

Pain Management