Arenicin-1 vs Met-enkephalin
Head-to-head comparison of Arenicin-1 (Arenicin-1) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Arenicin-1 | Met-enkephalin |
|---|---|---|
| Category | Marine-Derived | Pain Management |
| Full Name | Arenicin-1 | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 2079 Da | 573.67 Da |
| Half-Life | n/a | 1-5 minutes in plasma |
| Amino Acids | 21 | 5 |
| Typical Dose | n/a | 0.1-5 ug per animal |
| Route | preclinical | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 76 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
Arenicin-1 Benefits
- ✓antimicrobial
- ✓anti-biofilm
- ✓membrane-active
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Arenicin-1 Dosing
bacterial infection|biofilm disruption
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Arenicin-1 Side Effects
- ⚠Arenicola marina
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
Arenicin-1
Marine annelid peptide with strong preclinical antibacterial activity and a stable structural motif that is useful for peptide engineering.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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