Arenicin-1 vs Endomorphin-1
Head-to-head comparison of Arenicin-1 (Arenicin-1) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Arenicin-1 | Endomorphin-1 |
|---|---|---|
| Category | Marine-Derived | Pain Management |
| Full Name | Arenicin-1 | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 2079 Da | 610.71 Da |
| Half-Life | n/a | Minutes in plasma |
| Amino Acids | 21 | 4 |
| Typical Dose | n/a | 0.1-10 ug per animal |
| Route | preclinical | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 76 | 600 |
| Research Status | Pre-clinical | Pre-clinical |
Arenicin-1 Benefits
- ✓antimicrobial
- ✓anti-biofilm
- ✓membrane-active
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Arenicin-1 Dosing
bacterial infection|biofilm disruption
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Arenicin-1 Side Effects
- ⚠Arenicola marina
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
Arenicin-1
Marine annelid peptide with strong preclinical antibacterial activity and a stable structural motif that is useful for peptide engineering.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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