Arenicin-1 vs DADLE
Head-to-head comparison of Arenicin-1 (Arenicin-1) and DADLE ([D-Ala2, D-Leu5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Arenicin-1 | DADLE |
|---|---|---|
| Category | Marine-Derived | Pain Management |
| Full Name | Arenicin-1 | [D-Ala2, D-Leu5]-enkephalin |
| Molecular Weight | 2079 Da | 569.67 Da |
| Half-Life | n/a | 5-20 minutes in plasma |
| Amino Acids | 21 | 5 |
| Typical Dose | n/a | 0.01-2 ug per animal |
| Route | preclinical | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 76 | 450 |
| Research Status | Pre-clinical | Pre-clinical |
Arenicin-1 Benefits
- ✓antimicrobial
- ✓anti-biofilm
- ✓membrane-active
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Arenicin-1 Dosing
bacterial infection|biofilm disruption
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Arenicin-1 Side Effects
- ⚠Arenicola marina
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Research Overview
Arenicin-1
Marine annelid peptide with strong preclinical antibacterial activity and a stable structural motif that is useful for peptide engineering.
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
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