Urodilatin
Human Urodilatin (Atrial Natriuretic Peptide 95-126)
32 Amino Acids · MW: ~3,465 Da
Amino Acids
32
Molecular Weight
~3,465 Da
Half-life
~10–20 min
Research Score
4.4
Studies
200
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Urodilatin?
A 32-amino-acid natriuretic peptide derived from the ANP precursor and produced predominantly in the kidney. It increases sodium excretion, lowers vascular resistance, and supports renal perfusion.
Key Benefits & Mechanisms
natriuresis
vasodilation
renal perfusion support
blood-pressure reduction
Research Summary
Urodilatin has been studied as a renal natriuretic and vasodilatory peptide with interest in acute heart failure and cardiorenal syndrome. Research suggests it can improve sodium handling while reducing preload and blood pressure.
Related Peptides
Carperitide
Recombinant human atrial natriuretic peptide (α-hANP)
Recombinant human atrial natriuretic peptide used mainly in acute heart failure and perioperative volume overload. It promotes natriuresis, vasodilation, and suppression of RAAS signaling to lower preload and afterload.
CardiovascularNesiritide
Recombinant human B-type natriuretic peptide (BNP-32)
Synthetic BNP used to counteract fluid overload and elevated cardiac filling pressures. It increases cyclic GMP, causing venous and arterial vasodilation plus natriuresis.
CardiovascularUlaritide
Synthetic human urodilatin
Urodilatin is a renal natriuretic peptide derived from the proANP precursor and studied as an IV heart-failure therapy. It produces strong natriuresis and vasodilation with a relatively rapid onset.
CardiovascularCenderitide
CD-NP chimeric natriuretic peptide
Cenderitide is a designer natriuretic peptide combining features of CNP and dendroaspis natriuretic peptide. It was engineered to provide balanced natriuretic and vasodilatory activity with potential renal-sparing effects.
Cardiovascular