Ularitide
Synthetic human urodilatin
32 Amino Acids · MW: ≈3,463 Da
Amino Acids
32
Molecular Weight
≈3,463 Da
Half-life
≈4–10 minutes
Research Score
4.1
Studies
70
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Ularitide?
Urodilatin is a renal natriuretic peptide derived from the proANP precursor and studied as an IV heart-failure therapy. It produces strong natriuresis and vasodilation with a relatively rapid onset.
Key Benefits & Mechanisms
natriuresis
diuresis
blood-pressure reduction
renal tubular sodium excretion
Research Summary
Ularitide has been evaluated in acute heart failure and cardiorenal syndrome programs. Clinical studies showed clear biomarker and hemodynamic effects, but definitive outcome advantages have been difficult to prove.
Related Peptides
Carperitide
Recombinant human atrial natriuretic peptide (α-hANP)
Recombinant human atrial natriuretic peptide used mainly in acute heart failure and perioperative volume overload. It promotes natriuresis, vasodilation, and suppression of RAAS signaling to lower preload and afterload.
CardiovascularNesiritide
Recombinant human B-type natriuretic peptide (BNP-32)
Synthetic BNP used to counteract fluid overload and elevated cardiac filling pressures. It increases cyclic GMP, causing venous and arterial vasodilation plus natriuresis.
CardiovascularCenderitide
CD-NP chimeric natriuretic peptide
Cenderitide is a designer natriuretic peptide combining features of CNP and dendroaspis natriuretic peptide. It was engineered to provide balanced natriuretic and vasodilatory activity with potential renal-sparing effects.
CardiovascularCNP
Human C-type natriuretic peptide (CNP-22)
CNP is an endogenous natriuretic peptide that signals through NPR-B and increases cGMP. In cardiovascular research it is studied for vasoprotective, anti-fibrotic, and endothelial-supportive actions.
Cardiovascular