CNP
Human C-type natriuretic peptide (CNP-22)
22 Amino Acids · MW: ≈2,477 Da
Amino Acids
22
Molecular Weight
≈2,477 Da
Half-life
≈2–4 minutes
Research Score
3.8
Studies
120
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is CNP?
CNP is an endogenous natriuretic peptide that signals through NPR-B and increases cGMP. In cardiovascular research it is studied for vasoprotective, anti-fibrotic, and endothelial-supportive actions.
Key Benefits & Mechanisms
endothelial support
anti-fibrotic effects
vascular relaxation
cGMP signaling
Research Summary
CNP has extensive mechanistic literature in vascular biology, cardiac remodeling, and endothelial function. It remains a major research tool for understanding natriuretic peptide biology rather than a standard heart-failure drug.
Related Peptides
Carperitide
Recombinant human atrial natriuretic peptide (α-hANP)
Recombinant human atrial natriuretic peptide used mainly in acute heart failure and perioperative volume overload. It promotes natriuresis, vasodilation, and suppression of RAAS signaling to lower preload and afterload.
CardiovascularNesiritide
Recombinant human B-type natriuretic peptide (BNP-32)
Synthetic BNP used to counteract fluid overload and elevated cardiac filling pressures. It increases cyclic GMP, causing venous and arterial vasodilation plus natriuresis.
CardiovascularUlaritide
Synthetic human urodilatin
Urodilatin is a renal natriuretic peptide derived from the proANP precursor and studied as an IV heart-failure therapy. It produces strong natriuresis and vasodilation with a relatively rapid onset.
CardiovascularCenderitide
CD-NP chimeric natriuretic peptide
Cenderitide is a designer natriuretic peptide combining features of CNP and dendroaspis natriuretic peptide. It was engineered to provide balanced natriuretic and vasodilatory activity with potential renal-sparing effects.
Cardiovascular