Nesiritide
Recombinant human B-type natriuretic peptide (BNP-32)
32 Amino Acids · MW: ≈3,465 Da
Amino Acids
32
Molecular Weight
≈3,465 Da
Half-life
≈18–20 minutes
Research Score
4.5
Studies
300
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Nesiritide?
Synthetic BNP used to counteract fluid overload and elevated cardiac filling pressures. It increases cyclic GMP, causing venous and arterial vasodilation plus natriuresis.
Key Benefits & Mechanisms
hemodynamic unloading
natriuresis
vasodilation
dyspnea relief
Research Summary
Nesiritide was developed for acute decompensated heart failure and studied in multiple randomized trials. It reliably improves short-term hemodynamics, though outcome benefits beyond symptom relief remain limited.
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