Terlipressin
Triglycyl-lysine vasopressin
12 Amino Acids · MW: 1227.37 Da
Amino Acids
12
Molecular Weight
1227.37 Da
Half-life
4-6 hours
Research Score
4.5
Studies
1400
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Terlipressin?
A synthetic vasopressin prodrug that is enzymatically converted to lysine vasopressin in vivo. It is used in portal hypertension and hepatorenal syndrome because of its potent vasoconstrictive profile.
Key Benefits & Mechanisms
splanchnic vasoconstriction
variceal-bleed control
hepatorenal-syndrome therapy
MAP support
Research Summary
Terlipressin has extensive literature in critical care, hepatology, and vasoactive peptide pharmacology. Studies compare it with octreotide, norepinephrine, and endoscopic strategies for bleeding and cirrhosis-related circulatory dysfunction.
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