Carbetocin
1-deamino-1-monocarba-2-O-methyltyrosine oxytocin
9 Amino Acids · MW: 988.17 Da
Amino Acids
9
Molecular Weight
988.17 Da
Half-life
20-40 minutes
Research Score
4.6
Studies
1800
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Carbetocin?
A long-acting oxytocin analog engineered to resist rapid enzymatic degradation while preserving oxytocin receptor agonism. It is widely used and studied for postpartum hemorrhage prevention because of its prolonged uterotonic effect.
Key Benefits & Mechanisms
longer uterotonic duration
postpartum hemorrhage prevention
receptor-selective oxytocin agonism
reduced redosing
Research Summary
Carbetocin has strong clinical literature supporting single-dose uterotonic use, especially where prolonged oxytocin exposure is beneficial. Comparative studies focus on effectiveness, stability, and fewer repeat doses versus oxytocin infusions.
Related Peptides
Oxytocin
Neurohypophysial Hormone Peptide
Oxytocin is a naturally occurring nonapeptide hormone produced in the hypothalamus. Known as the "bonding hormone," it plays crucial roles in social behavior, emotional regulation, trust, and pair bonding. FDA-approved (Pitocin) for labor induction. Being studied for autism, anxiety, and PTSD.
PerformanceAtosiban
Atosiban (synthetic oxytocin receptor antagonist)
A synthetic peptide antagonist of the oxytocin receptor with vasopressin cross-reactivity at higher concentrations. It is a key compound for tocolysis and for probing oxytocin receptor signaling in reproductive biology.
HormonalTerlipressin
Triglycyl-lysine vasopressin
A synthetic vasopressin prodrug that is enzymatically converted to lysine vasopressin in vivo. It is used in portal hypertension and hepatorenal syndrome because of its potent vasoconstrictive profile.
HormonalMesotocin
Mesotocin (oxytocin homolog)
A naturally occurring oxytocin-like nonapeptide found across many non-mammalian vertebrates. It is a standard comparative endocrinology tool for studying social behavior, reproduction, and ancestral neurohypophyseal signaling.
Hormonal