Atosiban
Atosiban (synthetic oxytocin receptor antagonist)
9 Amino Acids · MW: 994.15 Da
Amino Acids
9
Molecular Weight
994.15 Da
Half-life
1.5-2.8 hours
Research Score
4.4
Studies
900
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Atosiban?
A synthetic peptide antagonist of the oxytocin receptor with vasopressin cross-reactivity at higher concentrations. It is a key compound for tocolysis and for probing oxytocin receptor signaling in reproductive biology.
Key Benefits & Mechanisms
tocolysis
oxytocin receptor blockade
preterm labor research
uterine contractility reduction
Research Summary
Atosiban has a large obstetric literature as an oxytocin/vasopressin receptor antagonist, especially for short-term suppression of preterm labor. Research also uses it to interrogate receptor pharmacology, contractility, and pregnancy-associated physiology.
Related Peptides
Carbetocin
1-deamino-1-monocarba-2-O-methyltyrosine oxytocin
A long-acting oxytocin analog engineered to resist rapid enzymatic degradation while preserving oxytocin receptor agonism. It is widely used and studied for postpartum hemorrhage prevention because of its prolonged uterotonic effect.
HormonalTerlipressin
Triglycyl-lysine vasopressin
A synthetic vasopressin prodrug that is enzymatically converted to lysine vasopressin in vivo. It is used in portal hypertension and hepatorenal syndrome because of its potent vasoconstrictive profile.
HormonalMesotocin
Mesotocin (oxytocin homolog)
A naturally occurring oxytocin-like nonapeptide found across many non-mammalian vertebrates. It is a standard comparative endocrinology tool for studying social behavior, reproduction, and ancestral neurohypophyseal signaling.
HormonalCRH
Corticotropin-Releasing Hormone
Hypothalamic peptide that drives pituitary ACTH release and activates the stress axis. It is widely used in research to model cortisol and HPA-axis responses.
Hormonal