Super Mini-B

SP-B miniaturized analog

41 Amino Acids · MW: ~5 kDa

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Amino Acids

Molecular Weight

~5 kDa

Half-life

unknown; formulation dependent

Research Score

4.4

Studies

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Super Mini-B?

Super Mini-B is an engineered surfactant protein B analog with a stabilized helix-turn-helix structure. It is built to improve adsorption, film resilience, and resistance to surfactant inactivation in damaged lungs.

Key Benefits & Mechanisms

improves adsorption

resists inhibition by plasma proteins

supports gas exchange

Research Summary

Super Mini-B has repeatedly outperformed simpler SP-B mimics in biophysical and animal studies. It is a leading candidate for next-generation surfactant replacement, but it remains experimental.

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