SP-C33Leu
Surfactant protein C analogue
33 Amino Acids · MW: ~3.8-4.5 kDa
Amino Acids
33
Molecular Weight
~3.8-4.5 kDa
Half-life
unknown; formulation dependent
Research Score
4.2
Studies
77
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is SP-C33Leu?
SP-C33Leu is a synthetic analog of human surfactant protein C designed to be more stable than the native peptide. It helps form and stabilize surfactant films at the alveolar air-liquid interface.
Key Benefits & Mechanisms
enhances surfactant film formation
improves biophysical stability
may reduce atelectasis
Research Summary
SP-C33Leu has been studied as a more stable replacement for native SP-C in surfactant preparations. Data support potent surface activity in model systems and animal studies, with ongoing interest in translational respiratory use.
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