Sinapultide
KL4 peptide; synthetic surfactant protein mimic
21 Amino Acids · MW: ~2.5 kDa
Amino Acids
21
Molecular Weight
~2.5 kDa
Half-life
short, minutes to hours in airway fluid
Research Score
4.6
Studies
88
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Sinapultide?
Sinapultide is a 21-residue amphipathic peptide designed to mimic the biophysical activity of pulmonary surfactant proteins. It has been studied in inhaled and intratracheal surfactant formulations for neonatal respiratory distress and other forms of respiratory failure.
Key Benefits & Mechanisms
reduces alveolar surface tension
improves lung compliance
supports oxygenation
Research Summary
Early translational and clinical work suggests surfactant-mimetic activity, with the strongest evidence coming from formulations containing the peptide rather than the peptide alone. It remains an investigational respiratory peptide rather than an approved standalone drug.
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