Mini-B
Synthetic SP-B(1-25) analog
34 Amino Acids · MW: ~4-5 kDa
Amino Acids
34
Molecular Weight
~4-5 kDa
Half-life
unknown; formulation dependent
Research Score
4.2
Studies
79
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Mini-B?
Mini-B is a synthetic peptide based on the N- and C-terminal bioactive regions of surfactant protein B. It is designed to preserve surfactant spreading while being more stable than native SP-B fragments.
Key Benefits & Mechanisms
promotes phospholipid spreading
improves surfactant film stability
may protect injured alveoli
Research Summary
Mini-B has shown strong activity in vitro and in animal models of surfactant deficiency and acute lung injury. Human respiratory use remains preclinical, but it is one of the best-studied SP-B mimetic peptides.
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