Piperlongumine
Piperlongumine
N/A Amino Acids · MW: 317.34 Da
Amino Acids
N/A
Molecular Weight
317.34 Da
Half-life
N/A (not well characterized in humans)
Research Score
4.1
Studies
60
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Piperlongumine?
Piperlongumine is a natural alkaloid from long pepper that has been investigated as a senolytic and redox-modulating research compound. It is of interest because senescent cells often rely on elevated antioxidant defenses that piperlongumine may disrupt.
Key Benefits & Mechanisms
senescent cell vulnerability targeting
oxidative stress modulation
anti-inflammatory signaling
cellular stress reduction
Research Summary
Preclinical studies show piperlongumine can preferentially impair senescent cells and may reduce senescence-associated markers in model systems. Its anti-aging interest is driven by a narrow mechanistic focus on oxidative stress dependencies, though tolerability remains a major question.
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