Niacin
Nicotinic Acid
N/A Amino Acids · MW: 123.11 Da
Amino Acids
N/A
Molecular Weight
123.11 Da
Half-life
0.5-1.0 hours
Research Score
4.1
Studies
1200
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Niacin?
A vitamin B3 form that feeds the Preiss-Handler pathway to NAD+, making it one of the most established human NAD+ boosters in the literature. It is not a direct sirtuin activator, but raising NAD+ availability can support sirtuin-dependent repair and metabolic signaling.
Key Benefits & Mechanisms
raises NAD+ pools
supports sirtuin-dependent signaling
supports energy metabolism
may aid vascular health
Research Summary
Niacin has decades of clinical use and extensive mechanistic literature on NAD+ metabolism, although anti-aging outcomes are still indirect rather than proven. It remains a foundational reference compound when discussing NAD+ restoration and longevity biology.
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